The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
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NMNAT3 is protective against the effects of neonatal cerebral hypoxia‐ischemia
OBJECTIVE To determine whether the NAD+ biosynthetic protein, nicotinamide mononucleotide adenylyltransferase-3 (NMNAT3), is a neuroprotective inducible enzyme capable of decreasing cerebral injury after neonatal hypoxia-ischemia (H-I) and reducing glutamate receptor-mediated excitotoxic neurodegeneration of immature neurons. METHODS Using NMNAT3-overexpressing mice we investigated whether in...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2017
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-016-0504-9